pentobarbital will lower the level or outcome of carvedilol by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Watch.pentobarbital will reduce the extent or impact of buprenorphine buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Approximately 25 to 50 % of a dose of aprobarbital or phenobarbit